IL-39 Reduces Proliferation and Promotes Apoptosis of Bladder Cancer by Altering the Activity of Cyclin E and Fas

Background/Aim: This study was designed to investigate the effect of IL-39 on T24 bladder cancer (BC) cell line survival and growth. Materials Methods: In order assess direct survival, proliferation, apoptosis BC cells, we utilized a clonogenic assay, proliferation caspase-3 activity kits. Potential proliferative apoptotic molecular mechanisms were evaluated by RT-PCR. Results: Treatment cells with resulted in significant reduction percentage colonies. The anti-tumor correlated strongly decrease cyclin E, combination an increase mRNA levels Fas. Conclusion: impedes growth inhibiting promoting apoptosis. ability modulate gene transcription neoplastic shows promise warrants further research immunotherapy.